Specific Interaction between Ca2+ and Anionic Lipids in Cancer Cells along with Apoptosis
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概要
- 論文の詳細を見る
Markedly inhibitory effects of Ca2+ on the growth of human tumor cells were attained through the induction of apoptosis in vitro. On the other hand, a good correlation between the growth inhibition effects of Ca2+ and the amounts of phosphatidylserines (PS) in the cell membranes (plasma membranes) was obtained. Furthermore, the decrease of membrane fluidity and the localization of lipid microdomains “lipid rafts” in the cell membranes were observed in the presence of Ca2+. The findings in this study suggest that Ca2+ could induce apoptosis toward tumor cells through the localization of lipid rafts in plasma membranes by the specific interactions between extracellular Ca2+ and PS.
- 日本薬学会の論文
著者
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GOTO Koichi
Division of Thoracic Oncology, National Cancer Center Hospital East
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Goto K
Graduate Course Of Applied Life Science Sojo University
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Goto Koichi
Division Of Cardiology Sakurabashi Watanabe Hospital
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UEOKA Ryuichi
Division of Applied Chemistry, Graduate School of Kumamoto Institute of Technology
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Komizu Yuji
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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Komizu Yuji
Division Of Applied Life Science Graduate School Of Engineering Sojo University
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Goto K
Div. Of Applied Life Sci. Graduate School Of Engineering Sojo Univ.
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Tatsumi Kazuki
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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Nagata Toshihiro
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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Goto Koichi
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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