New Cancer Immunotherapy Using Autologous Lymphocytes Activated with Trastuzumab
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概要
- 論文の詳細を見る
It is well known that trastuzumab (TTZ) is molecular target drug for breast cancer overexpressing human epidermal growth factor receptor 2 (HER2). Novel immunotherapy by human peripheral blood mononuclear cells (PBMCs) activated with TTZ were examined. Proliferation of lymphocytes after adding of TTZ was obtained. Furthermore, lymphocytes activated with TTZ inhibited growth of breast cancer cells in vitro. It is noteworthy that remarkably high cellular cytotoxicity in lymphocytes activated with TTZ compared with that of CD3- and lymphokine (interleukin (IL)2)-activated killer (CD3-LAK) cells commonly used in immunotherapy were revealed.
- 公益社団法人 日本薬学会の論文
著者
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UEOKA Ryuichi
Division of Applied Chemistry, Graduate School of Kumamoto Institute of Technology
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ICHIHARA Hideaki
Division of Applied Life Science, Graduate School of Engineering, Sojo University
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Nakagawa Shinichirou
Immuno-medical Lab, Omote Sando Yoshida Hospital
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Matsuoka Yusuke
Immuno-medical Lab, Omote Sando Yoshida Hospital
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Yoshida Hitoji
Immuno-medical Lab, Omote Sando Yoshida Hospital
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Yoshida Kenshi
Immuno-medical Lab, Omote Sando Yoshida Hospital
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