Ionic Liquid-in-Oil Microemulsions as Potential Carriers for the Transdermal Delivery of Methotrexate
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概要
- 論文の詳細を見る
Ionic liquid-in-oil (IL/o) microemulsion (ME) techniques have been employed to increase the solubility of sparingly soluble drugs and enhance the extent of their topical and transdermal delivery. Methotrexate (MTX) has been used as a model drug in the current study. The size and size distributions of the ME droplets in the presence and in the absence of MTX were determined by dynamic light scattering analysis. The mean droplet diameter of the ME droplets containing 4 mg/mL of MTX was less than 20 nm, and smaller than the corresponding value observed in the absence of MTX. MTX was incorporated into IL droplets as well as other formulations and its permeation across Yucatan micropig (YMP) porcine skin evaluated. The use of IL/o ME has been shown to dramatically increase MTX administration. The results obtained in this study reveal the versatility of IL/o MEs as efficient drug delivery systems for sparingly soluble drugs.
- The Society of Chemical Engineers, Japanの論文
著者
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GOTO Masahiro
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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Tamura Miki
Department Of Breast Surgery Cancer Institute Hospital
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Kamiya Noriho
Department Of Applied Chemistry Faculty Of Engineering Kyushu University
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Goto Masahiro
Department Of Applied Biological Chemistry The University Of Tokyo
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Yoshiura Hiromu
Technical Department, BioKyowa Inc.
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Aso Makoto
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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Tamura Miki
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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