The Cooperativity of Human Fetal and Adult Hemoglobins is Optimized : A Consideration Based on the Effectiveness of the Bohr Shift(Physiology)
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概要
- 論文の詳細を見る
The physiological significance of the cooperativity of human hemoglobin (Hb) is considered from the viewpoint of the effectiveness of the Bohr shift at the sites of O_2 release and uptake across the placental membrane. The effects of the Bohr shift was examined by changing the O_2 saturation of Hb (S_<(pO2)>) per unit change in P50, -dS_<(pO2)>/dP_<50>, where P5o is partial pressure of O_2 at half saturation. The Bohr shift at the sites of O_2 uptake and release was found to be highly effective in both fetal and maternal bloods at physiological degree of cooperativity (Hill's coefficient, n=2.65). From the results obtained in this paper, it is concluded that the positions of OECs of fetal and maternal Hbs are regulated to receive a maximal benefit from the Bohr shift, and that a relatively low n value of human tetrameric Hb is adequate for the O_2 and CO_2 exchange across the placental membrane.
- 社団法人日本動物学会の論文
- 2003-01-25
著者
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Kobayashi Michisuke
Department of Physics, Faculty of Science, Niigata University
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Imai K
Deparment Of Material Chemistry Faculty Of Engineering Hosei University
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Kobayashi M
Department Of Biology Faculty Of Science Niigata University
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Kobayashi Michisuke
Department Of Physice Nigata University
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Kobayashi Michiyori
Department of Biology, Faculty of Science, Niigata University
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Sasagawa Keisuke
Graduate School of Science and Technology, Niigata University
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Imai Kiyohiro
Laboratory of Nanobiology, Graduate School of Frontier Biosciences, Osaka University
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Kobayashi Makito
Department Of Aquatic Bioscience Graduate School Of Agricultural And Life Sciences The University Of
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Miki Makoto
Graduate School Of Science And Technology Niigata University
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Kobayashi M
Epma Laboratory Niigata University Center For Instrumental Analysis
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Zhang Van
Graduate school of Science and Technology, Niigata University
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Ishigaki K
Deparment Of Material Chemistry Faculty Of Engineering Hosei University
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Zhang Van
Graduate School Of Science And Technology Niigata University
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Sasagawa Keisuke
Graduate School Of Science And Technology Niigata University
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Kobayashi M
Ishigaki Tropical Station Seikai National Fisheries Research Institute
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Kobayashi Michiyori
Department Of Biology Faculty Of Science Niigata University
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Zhang Yan
Graduate Program Of Human Sensing And Functional Sensor Engineering Graduate School Of Science And E
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