Contribution of Cooperativity and the Bohr Effect to Efficient Oxygen Transport by Hemoglobins from Five Mammalian Species(Physiology)

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概要

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• By using published experimental values of the standard oxygen (O_2) equilibrium curve and the in vivo arterial and venous O_2 pressure (PO_2) of fetal and maternal blood in five mammalian species (human, cow, pig, sheep, and horse), we investigated the relationship between the efficiency of O_2 delivery and the effectiveness of the Bohr shift, and discussed the significance of cooperativity for mammalian Hb. The O_2 delivery of fetal blood was more efficient than that of maternal blood, and the effectiveness of the Bohr shift at both O_2 loading and release sites of fetal blood was high. A linear relationship was observed between the efficiency of O_2 delivery and the effectiveness of the Bohr shift at O_2 loading sites of the five mammalian species. In both fetal and maternal blood, the theoretically obtained optimal P_<50> value for O_2 delivery (optP_<50(OD)>) was nearly equal to the optimal P_<50> value for the effectiveness of the Bohr shift at the O_2 loading site (optP_<50(BS)(loading)>). This phenomenon was favorable for fetal blood to uptake O_2 from maternal blood with the aid of the Bohr shift and to deliver a large amount of O_2 to the tissues. The optP_<50>s for the effectiveness of the Bohr shift at given arterial PO_2 (P_aO_2) and venous PO_2 (P_vO_2) were derived as follows: optP_<50(BS)(loading)> = P_aO_2((n+1)/(n-1))^<1/n>, and optP_<50(BS)(release)> = P_vO_2((n+1)/(n-1))^<1/n>. The relationship between in vivo PO_2s and n, P_aO_2/P_vO_2 = ((n+1)/(n-1))^<2/n>, was derived by letting optP_<50> for the efficiency of O_2 delivery be equal to that for the effectiveness of the Bohr shift.

• 社団法人日本動物学会の論文
• 2006-01-25

著者

• Zhang Y

  Graduate School Of Science And Technology Niigata University

• Imai K

  Deparment Of Material Chemistry Faculty Of Engineering Hosei University

• Imai Kiyohiro

  Department Of Physiology And Biosignaling Graduate School Of Medicine Osaka University

• Kobayashi M

  Department Of Biology Faculty Of Science Niigata University

• Kobayashi Keiko

  Graduate School Of Science And Technology Niigata University

• Zhang Yan

  Graduate School of Science and Technology, Niigata University

• Kitazawa Kazuki

  Department of Biology, Faculty of Science, Niigata University

• Kobayashi Michiyori

  Department of Biology, Faculty of Science, Niigata University

• Kobayashi Makito

  Department Of Aquatic Bioscience Graduate School Of Agricultural And Life Sciences The University Of

• Imai Kiyohiro

  Deparment Of Material Chemistry Faculty Of Engineering Hosei University

• Kobayashi Kana

  Faculty Of Letters Keio University

• Kobayashi K

  Graduate School Of Humanities And Sciences Nara Women's University

• Kobayashi M

  Epma Laboratory Niigata University Center For Instrumental Analysis

• Kitazawa Kazuki

  Department Of Biology Faculty Of Science Niigata University

• Ishigaki K

  Deparment Of Material Chemistry Faculty Of Engineering Hosei University

• Kobayashi M

  Ishigaki Tropical Station Seikai National Fisheries Research Institute

• Zhang Yan

  Graduate School Of Science And Technology Niigata University

• Kobayashi Michiyori

  Department Of Biology Faculty Of Science Niigata University

• Zhang Yan

  Graduate Program Of Human Sensing And Functional Sensor Engineering Graduate School Of Science And E

• Kobayashi K

  Department Of Regulation Biology Faculty Of Science Saitama University

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