The Oxygen Transport Efficiency of Arthropod Hemocyanins
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概要
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The efficiency in O_2 transport of an O_2 carrier is best expressed by the slope of O_2 equilibrium curve(dS/dP), where S and P denote the fractional O_2 saturation of the carrier and the partial O_2 pressure, respectively. The aim of this study is to characterize the O_2 binding to arthropod hemocyanins (Hcs) in term of the O_2 transport efficiency, and for that purpose we have reexamined the previously published O_2 equilibrium data and their mathematical interpretations. Examination of the data for 6- and 12-meric Hcs from lobsters (Panulirus japonicus, Procambarus clarkii) revealed the relationship P_<dmax> < P_<50> ≈ P_<nmax>, where P_<dmax>, P_<50> and P_<nmax> denote the P at which dS / dP is maximized, P at half-saturation and P at which the Hill coefficient is maximized, respectively. On the other hand, 48-meric Hcs from horseshoe crabs (Tachypleus gigas, and Limulus polyphemus) gave the relationship P_<dmax> ≤ P_<50><P_<nmax>, when the O_2 binding is cooperative. The results indicate that Hc functions most effectively at P values lower than that expected from the maximal degree of cooperativity, similarly to the previous results obtained for human hemoglobin (Hb) [6]. The profile of dS/dP vs. P curves for lobster Hcs was similar to that of Hb, showing a single maximum and a relatively symmetric shape. On the other hand, the curves for horseshoe crab Hcs showed multiple maxima tailing in the low P range, indicating that the O_2 transport efficiency is high even under hypoxic circumstances. As far as the O_2 transport efficiency is concerned, horseshoe crab Hcs are regarded as unique, and the features seem to reflect their uniqueness in the molecular architecture and the mode of allosteric transition.
- 社団法人日本動物学会の論文
- 1995-06-15
著者
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WATANABE Miho
Department of Industrial Chemistry, Faculty of Science and Technology, Tokyo University of Science
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Watanabe M
Yamaguchi Univ. Yamaguchi Jpn
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Kobayashi Michiyori
Department of Biology, Faculty of Science, Niigata University
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Kitayama Kazuko
Department of Biology, Faculty of Science, Niigata University
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Makino Nobuo
Department Of Biology Faculty Of Science Niigata University
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Kitayama Kazuko
Department Of Biology Faculty Of Science Niigata University
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Watanabe Miho
Department Of Biology Faculty Of Science Niigata University
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Kobayashi Michiyori
Department Of Biology Faculty Of Science Niigata University
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