A New Look on the Position of the Oxygen Equilibrium Curve of Human Adult Hemoglobin at Rest and during Exercise with Special Reference to the Effectiveness of the Bohr Shift(Physiology)

概要

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The position of oxygen equilibrium curve (OEC) for human adult Hb at rest is optimized with respect to the effectiveness of the Bohr shift which is measured by the change in O_2 saturation at a venous O_2 pressure of 40 torr per unit change in partial pressure of O_2 at half saturation (dS_<(40)>/dP_<50>). The effectiveness of the Bohr shift at the physiological P_<50> of 27 torr depends on the cooperativity of O_2 binding calculated by the Hill coefficient n, being maximized at n=4. The effectiveness of the Bohr shift during exercise, which was expressed as dS_<(PvO2)>/dP_<50>, was the highest at the PvO_2 (venous O_2 pressure) of 28 torr. The effectiveness of the Bohr shift at PvO_2 of 28 torr increased with increases n value (n value ranged from 2.65 to 3.27), while below PvO_2 of 15 torr the opposite was true. As a whole, the position of the OEC of human adult Hb at rest is optimized with respect to the effectiveness of the Bohr shift while the efficiency of O_2 delivery is moderately maintained. On the other hand, during exercise the position of the OEC is adjusted to make the efficiency of O_2 delivery at high levels while the effectiveness of the Bohr shift is maintained at the same level as that at rest.
社団法人日本動物学会の論文
2001-09-20