Significance of Oxygen Affinity of Fetal and Adult Human Hemoglobins
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概要
- 論文の詳細を見る
The oxygen equilibrium curves of human fetal and adult hemoglobins were reconstructed from the published Adair constants. The curves were then analyzed theoretically with respect to the amount of transferred oxygen, which is directly related to the saturation difference (ΔS) of hemoglobin with oxygen in the artery and vein. In fetal blood, the oxygen affinity is optimized so as to provide the maximal ΔS value in the fetus oxygen environment. In adult blood, on the other hand, the ΔS value is far smaller than the theoretically obtained maximum, but it is most sensitive to the P_<50> changes around its physiological value of 27 torr. The present results imply that adult blood reserves an oxygen transport capacity for increased oxygen demands under resting conditions, and that the oxygen affinity is optimized so as to make the Bohr effect most effective to gaseous exchange.
- 社団法人日本動物学会の論文
- 1996-10-15
著者
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Imai K
Deparment Of Material Chemistry Faculty Of Engineering Hosei University
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Imai Kiyohiro
Department Of Physiology And Biosignaling Graduate School Of Medicine Osaka University
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Kobayashi Michiyori
Department of Biology, Faculty of Science, Niigata University
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Imai Kiyohiro
Deparment Of Material Chemistry Faculty Of Engineering Hosei University
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Kobayashi M
Epma Laboratory Niigata University Center For Instrumental Analysis
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Kimura Shoko
Graduate School of Science and Technology, Niigata University
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Kimura Shoko
Department of Biology, Faculty of Science, Niigata University
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Ishigaki Ken-Ichi
Information Processing Center, Niigata University
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Makino Nobuo
Ibaraki Prefectural University of Health Science
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Kimura Shoko
The Research Institute Of Environmental Medicine Nagoya University
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Makino N
Ibaraki Prefectural University Of Health Science
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Ishigaki K
Deparment Of Material Chemistry Faculty Of Engineering Hosei University
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Kobayashi Michiyori
Department Of Biology Faculty Of Science Niigata University
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