Functional Analysis of the Iron(II)Etiocorrphycene Incorporated in the Myoglobin Heme Pocket
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概要
- 論文の詳細を見る
The iron(II)complex of 2, 7, 12, 17-tetraethyl-3, 6, 11, 18-tetramethylcorrphycene, an isomeric heme, was complexed with apomyoglobin to examine the ligand binding ability of the novel macrocycle under physiological conditions. The reconstituted holoprotein was found to be functionally active at pH 7.4 and 20℃ and to bind oxygen and carbon monoxide reversibly with a half-saturation pressure at 6.7 and 3.5mmHg, respectively. Equilibrium affinities for these ligands are one to two orders of magnitude lower than those reported for native myoglobin. The functional anomaly was ascribed to the geometric and electronic strain on the iron(II)atom in the trapezoidal coordination core of corrphycene.
- 公益社団法人日本薬学会の論文
- 2001-03-01
著者
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Funasaki Noriaki
Department of Physical Chemsitry, Kyoto Pharmaceutical University
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Funasaki N
Department Of Physical Chemistry 21st Century Coe Program Kyoto Pharmaceutical University
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Funasaki Noriaki
Department Of Physical Chemistry Kyoto Pharmaceutical University
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Funasaki Noriaki
Dep. Of Biophysical Chemistry Kyoto Pharmaceutical Univ.
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NEYA Saburo
Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University
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Imai Kiyohiro
Department Of Physiology And Biosignaling Graduate School Of Medicine Osaka University
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Neya Saburo
Department Of Physical Chemistry Faculty Of Pharmaceutical Sciences Chiba University
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NAKAMURA MIHOKO
Department of Pediatrics, Faculty of Medicine, Kagoshima University
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NAGATOMO Shigenori
Institute for Molecular Science
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Funasaki Noriaki
Department Of Physical Chemistry 21st Century Coe Program Kyoto Pharmaceutical University
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Nagatomo Shigenori
Cneter For Integrative Bioscience Okazaki National Research Institutes
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Imai Kiyohiro
Deparment Of Material Chemistry Faculty Of Engineering Hosei University
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Nagatomo S
Osaka Univ. Osaka
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Nakamura Mihoko
Department Of Physical Chemistry Kyoto Pharmaceutical University
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Nakamura Mihoko
Department Of Chemistry Faculty Of Science Kanazawa University
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Funasaki Noriaki
Department of Biophysical Chemistry, Kyoto Pharmaceutical University
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