Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes
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概要
- 論文の詳細を見る
The masking mechanisms of the bitter taste of propantheline bromide (PB) and oxyphenonium (OB) bromide by native and modified cyclodextrins, saccharides, surfactants, organic acids, nonionic and anionic polymers, and other compounds were investigated with ion selective electrodes. The intensity of the bitter taste for a mixed solution of cyclodextrin with PB or OB was quantitatively explained from the observed electromotive force with the following assumptions: the complex and the masking agent do not have any tastes and the bitter taste is independent of other tastes. Sodium dodecyl sulfate reduced the bitter taste remarkably, and this reduction was also explicable on the basis of the same mechanism. Sodium taurodeoxycholate enhanced the bitter taste, because of its strong bitterness, although it formed 1:1 complexes with PB and OB. The masking mechanism of saccharides was ascribed to overcoming the weak bitterness of the drug by the strong sweetness. λ-Carrageenan suppressed the bitter taste remarkably. This suppression was ascribed to the binding of PB and OB to λ-carrageenan, the effect of the solution viscosity on the bitter taste, and the covering of the bitter taste receptor by λ-carrageenan. It was suggested that the moderate masking by other polymers was attributable to the effect of the solution viscosity or the receptor covering. Native and modified β-cyclodextrins, sodium dodecyl sulfate, λ-carrageenan, Tween 20, and sodium carboxymethyl cellulose are good masking agents for the bitter tastes of PB and OB. The drug ion selective electrode is a useful tool for understanding of the masking mechanism of the bitter taste, screening of masking agents, and estimation of appropriate concentrations of the masking agents.
- 社団法人日本薬学会の論文
- 2006-08-01
著者
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Hirota Shun
Nara Institute of Science and Technology
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Hirota S
Department Of Physical Chemistry 21st Century Coe Program Kyoto Pharmaceutical University:presto Jap
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HIROTA Shun
Department of Physical Chemistry, 21st Century COE Program, Kyoto Pharmaceutical University
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Funasaki Noriaki
Department of Physical Chemsitry, Kyoto Pharmaceutical University
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Funasaki N
Department Of Physical Chemistry 21st Century Coe Program Kyoto Pharmaceutical University
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Funasaki Noriaki
Department Of Physical Chemistry Kyoto Pharmaceutical University
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Funasaki Noriaki
Dep. Of Biophysical Chemistry Kyoto Pharmaceutical Univ.
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URATSUJI Ikumi
Department of Physical Chemistry and 21st Century COE Program, Kyoto Pharmaceutical University
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OKUNO Takashi
Department of Physical Chemistry and 21st Century COE Program, Kyoto Pharmaceutical University
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NEYA Saburo
Graduate School of Pharmaceutical Sciences, Chiba University
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NEYA Saburo
Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University
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Neya S
Graduate School Of Pharmaceutical Sciences Chiba University
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Neya Saburo
Department Of Physical Chemistry Graduate School Of Pharmaceutical Sciences Chiba University
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Neya Saburo
Department Of Physical Chemistry Kyoto Pharmaceutical University
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Neya Saburo
Graduate School Of Pharmaceutical Sciences Chiba University
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Neya Saburo
Kyoto Pharmaceutical University
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Hirota Shun
Dept Of Phys. Chem. Kyoto Pharm. Univ.:presto Jst
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Hirota Shun
Department Of Chemistry Graduate School Of Science And Research Center For Materials Science Ngoya U
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Okuno T
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Neya Saburo
Department Of Physical Chemistry Faculty Of Pharmaceutical Sciences Chiba University
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Funasaki Noriaki
Department Of Physical Chemistry 21st Century Coe Program Kyoto Pharmaceutical University
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Okuno Takashi
Department Of Physical Chemistry And 21st Century Coe Program Kyoto Pharmaceutical University
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Uratsuji Ikumi
Department Of Physical Chemistry And 21st Century Coe Program Kyoto Pharmaceutical University
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Okuno Takashi
Department Of Chemistry Faculty Of Science Yamagata University
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Funasaki Noriaki
Department of Biophysical Chemistry, Kyoto Pharmaceutical University
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