Localization of the Endogenous Cysteine Proteinase Inhibitor, Cystatin C, and the Cysteine Proteinase, Cathepsin B, to the Junctional Epithelium in Rat Gingiva
スポンサーリンク
概要
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The junctional epithelium (JE) is a primary site of defense against periodontal pathogens. Cystatin C is an endogenous inhibitor of cysteline proteinases such as cathepsin B and also has antibacterial actions against periodontal pathogens. However, the distribution and role of cystatin C in JE have not been clarified. To investigate the function of cystatin C in the host defense at dentogingival junction, we examined the immunolocalization of cystatin C and cathepsin B in rat gingiva using light and electron microscopy. The JE (particularly the coronal portion) was immunopositive for cystatin C, and immunoelectron microscopy revealed that cystatin C was localized to the vesicular, granular, and vacuolar compartments of JE cells. The pattern of cathepsin B immunoreactivity in JE cells resembled that of cystatin C. Both cystatin C and cathepsin B appeared to be localized to endosomal/lysosomal compartments within JE cells. These findings suggest that cystatin C regulates cysteine proteinase activity and exerts antibacterial effects both in the lysosomal compartments of JE cells and in the intercellular spaces of the JE. Cystatin C is thus able to participate in host defense against periodontal pathogens at the dentogingival junction.
- 日本組織細胞化学会の論文
著者
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Zhang Jing-qi
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science
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YAMAZA Takayoshi
Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University
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KIDO Mizuho
Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University
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TANAKA Teruo
Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University
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Takata Takashi
Department Of Oral Biochemistry School Of Dentistry Health Sciences University Of Hokkaido
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Takuma Taishin
Department Of Oral Biochemistry School Of Dentistry Health Sciences University Of Hokkaido
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Kido Masahiro
Department Of Biosignal Research Tokyo Metropolitan Institute Of Gerontology:department Of Gastroent
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KAGIYA Tadayoshi
Department of Oral Anayomy II, Iwate Medical University School of Dentistry
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Tanaka Takaaki
Department Of Oral Surgery Asahi University School Of Dentistry
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Nishijima Katsushi
Departments of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University
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Zang Jin
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science
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Tanaka T
Department Of Oral Anatomy And Cell Biology Graduate School Of Dental Sciences Kyushu University
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DANJO Atsushi
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Saga University
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Mino Satoya
Departments of Oral Anatomy and Cell Biology, Kyushu University Graduate School of Dental Science
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Atsuta Ikiru
Departments of Oral Anatomy and Cell Biology, Kyushu University Graduate School of Dental Science
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Mino Satoya
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science
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Kido Mizuho
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science
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Kido Mizuho
Laboratory Of Oral Anatomy And Cell Biology Graduate School Of Dental Science Kyushu University
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Atsuta Ikiru
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science:fix
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Danjo Atsushi
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science:dep
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Taira Toshio
Fukushima Agricultural Experiment Station
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Tanaka Teruo
Department Of Biosystems Science Graduate School Of Science And Technology Kobe University
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Yamaza Takayoshi
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science
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Yamaza T
Laboratory Of Oral Anatomy And Cell Biology Graduate School Of Dental Science Kyushu University
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Kagiya Tadayoshi
Department Of Oral Anayomy Ii Iwate Medical University School Of Dentistry
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Kagiya Tadayoshi
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science:ora
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Nishijima Katsushi
Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science
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Tanaka Teruo
Department Of Anatomy Faculty Of Medicine Kyoto University:kansai Medical University
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Yamaza Takayoshi
Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University
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