Distribution of Inducible Nitric Oxide Synthase, Interleukin-1β, and Interleukin-1 Receptor in the Temporomandibular Joint of Normal Rats

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概要

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• Nitric oxide (NO) is generated from Larginine by NO synthase (NOS) and has multiple functions under both physiological and pathological conditions. One isoform of NOS, inducible NOS (iNOS) isexpressed in the cells such as macrophages after induction with various cytokines or mechanical stress. In this study, we investigated the distribution of iNOS, interleukin-1β (IL-1β) and its receptor, the IL-I receptor (IL-I R), in the synovial membrane of the temporomandibular joint (TMJ) of normal rats using immunolight and immunoelectron microscopy. By light microscopy, an immunopositive reaction for iNOS and IL-1β was found in the superficial cells of the synovial membrane of both the anterior and posterior portions of the articular disc. Immunoelectron microscopy revealed that iNOS-immunoreactive products were deposited in the cytoplasm and vesicles, and on the plasma membrane of type-A (macrophage-like) and B (fibroblast-like) cells of the superficial layer. IL-IR-positive products were found both on the plasma membrane and in the vesicles of type-A cells of the synovial lining, and were observed in macrophages in the sublining layer. These results reveal that iNOS and IL-1J3 localize to the synovial membrane of the rat TMJ under physiological conditions. Therefore, it is likely that autocrine/paracrine effects of IL-1J3 induce NO generation by iNOS via the IL-IR in type-A cells. It is considered that cyto-kine-induced NO may play an important role in the physiological maintenance, e.g. self-protection, by synovial lining cells of the synovial membrane in the TMJ.

• 日本組織細胞化学会の論文

著者

• YAMAZA Takayoshi

  Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University

• KIDO Mizuho

  Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University

• TANAKA Teruo

  Department of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University

• KOYANO Kiyoshi

  Department of Removable Prosthodontics, Faculty of Dental Science, Kyushu University

• TSUKIYAMA Yoshihiro

  Department of Removable Prosthodontics, Faculty of Dental Science, Kyushu University

• Tsukiyama Yoshihiro

  Departments Of Prosthetic Dentistry Graduate School Of Dental Science Kyushu University

• Takata Takashi

  Department Of Oral Biochemistry School Of Dentistry Health Sciences University Of Hokkaido

• Takuma Taishin

  Department Of Oral Biochemistry School Of Dentistry Health Sciences University Of Hokkaido

• Kido Masahiro

  Department Of Biosignal Research Tokyo Metropolitan Institute Of Gerontology:department Of Gastroent

• Murakami Rie

  Departments Of Oral Anatomy And Cell Biology Graduate School Of Dental Science Kyushu University:dep

• Tanaka Takaaki

  Department Of Oral Surgery Asahi University School Of Dentistry

• Masuda Keitaro

  Departments of Prosthetic Dentistry, Graduate School of Dental Science, Kyushu University

• Nishijima Katsushi

  Departments of Oral Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University

• Tanaka T

  Department Of Oral Anatomy And Cell Biology Graduate School Of Dental Sciences Kyushu University

• Kido Mizuho

  Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science

• Kido Mizuho

  Laboratory Of Oral Anatomy And Cell Biology Graduate School Of Dental Science Kyushu University

• Masuda Keitaro

  Departments Of Prosthetic Dentistry Graduate School Of Dental Science Kyushu University:departments

• Koyano Kiyoshi

  Department Of Oral Rehabilitation Faculty Of Dental Science Kyushu University

• Koyano Kiyoshi

  Departments Of Prosthetic Dentistry Graduate School Of Dental Science Kyushu University

• Taira Toshio

  Fukushima Agricultural Experiment Station

• Tanaka Teruo

  Department Of Biosystems Science Graduate School Of Science And Technology Kobe University

• Tsukiyama Yoshihiro

  Department Of Fixed Prosthodontics Faculty Of Dental Science Kyushu University

• Yamaza Takayoshi

  Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science

• Yamaza T

  Laboratory Of Oral Anatomy And Cell Biology Graduate School Of Dental Science Kyushu University

• Nishijima Katsushi

  Departments Of Oral Anatomy And Cell Biology Kyushu University Graduate School Of Dental Science

• Tanaka Teruo

  Department Of Anatomy Faculty Of Medicine Kyoto University:kansai Medical University

• Yamaza Takayoshi

  Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University

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