Distribution of O-GlcNAc Transferase in the Rat Pancreas
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概要
- 論文の詳細を見る
O-GlcNAc transferase(OGT)catalyzes the attachment of N-acetylglucosamine mono-saccharides to the hydroxyl group of serine or threonine residues of intracellular proteins and may play an important role in the hexosamine pathway. We examined the localization of OGT protein in the rat pancreas. Immunofluorescence staining with antibody raised against OGT stained both the exocrine acinar cells and endocrine islet cells. The acinar cell nucleus and the zymogen granule region were intensely stained. In the islets of Langerhans, especially in the A cells, intense staining with anti-OGT antibody was observed. Immuno-electron microscopy showed the OGT to be restricted to the enchromatin of the nucleus and around the secretory granules of exocrine acinar cells and endocrine islet cells. These results suggest that OGT is involved in the regulation of transcription and of granular secretion. Thus, O-GlcNAcylated protein(s) may be an important component of the glucose-sensing mechanism in the pancreas.
- 日本組織細胞化学会の論文
著者
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Akimoto Yoshihiro
Department of Anatomy, Kyorin University School of Medicine
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HIRANO Hiroshi
Department of Anatomy, Kyorin University School of Medicine
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Hart G
Department Of Biological Chemistry Johns Hopkins School Of Medicine
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Akimoto Yoshihiro
Department Of Anatomy Kyorin University School Of Medicine
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Hirano Hiroshi
Food Research Lab. Toyama Food Research Institute
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Hart Gerald
Department Of Biological Chemistry Johns Hopkins School Of Medicine
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Hirano Hiroshi
Second Department Of Pathology Hyogo College Of Medicine
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Akimoto Y
Department Of Anatomy Kyorin University School Of Medicine
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Hirano H
Univ. Hyogo Hyogo
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Hirano Hiroshi
Department Of Anatomy Kyorin University School Of Medicine
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Hirano Hiroshi
Department Of Anatomy Kansai Medical School
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Hirano Hiroshi
Department Of 2nd Anatomy Kyorin University School Of Medicine
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