Okadaic Acid Induces Marked Shape Change of Human Platelets.
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概要
- 論文の詳細を見る
Okadaic acid (OA) induced marked shape changes of human platelets but neither granule secretion nor increase in [Ca<SUP>2+</SUP>] i occurred. Morphological changes induced by OA were unique and different from those observed with thrombin mainly in two respects. One is that the pseudopods formed by OA treatment were longer and straighter than those by thrombin. The other is that no granule centralization was observed with OA-treatment, although central condensation of cytofilaments was observed as was with thrombin. The immunocytochemical analysis employing anti-myosin antibody revealed that myosin was distributed in the elongated pseudopods. Since OA induced phosphorylation of the 20-kDa myosin light chain (MLC20) corresponding to the change in shape of platalets but did not induce phosphorylation of the 47-kDa protein (pleckstrin) (Higashihara M. <I>et al</I>. FEBS Lett. 307: 206-210, 1992), these results suggest that phosphorylation of MLC20 plays an important role in OA-induced unique morphological changes of platelets.
- 日本平滑筋学会の論文
著者
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HIRANO Hiroshi
Department of Anatomy, Kyorin University School of Medicine
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Kawakami Hayato
Department Of 2nd Anatomy Kyorin University School Of Medicine
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Ikebe Mitsuo
Department Of Physiology Massachusetts Medical Center
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Higashihara Masaaki
The Fourth Department Of Internal Medicine Kitasato University School Of Medicine
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Kurokawa Kiyoshi
The First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Hirano Hiroshi
Department Of 2nd Anatomy Kyorin University School Of Medicine
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SONG Xiao-Hui
The First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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IKEBE Mitsuo
Department of Physiology and Biophysics, Case Western Reserve University
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HIGASHIHARA Masaaki
The First Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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