Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia
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概要
- 論文の詳細を見る
An antimicrobial agent trimethoprim-sulfamethoxazole (Tmp-Smx) does not usually cause electrolyte disturbances at regular doses, and few cases of Tmp-Smx-induced electrolyte imbalance have been reported in the English-language literature to date. Recently, however, we treated two patients with Pneumocystis carinii pneumonia who developed severe hyponatremia and hyperkalemia on administration of high-dose Tmp-Smx. These electrolyte disturbances were attributable to the direct effect of Tmp-Smx on the renal distal tubules, were reversible, and corrected by infusion of a sodium-enriched and potassium-free liquid. Therefore, it is suggested that even after electrolyte disturbances have occurred, high-dose Tmp-Smx therapy may be continued for severe infectious diseases under appropriate electrolyte correction.(Internal Medicine 34: 96-99, 1995)
- 社団法人 日本内科学会の論文
著者
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Kurokawa Kiyoshi
The First Department of Internal Medicine, Tokyo University School of Medicine
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Noto Hiroshi
The First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Takano Tomoko
The First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Kaneko Yoshiyasu
The First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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Kurokawa Kiyoshi
The First Department Of Internal Medicine Tokyo University School Of Medicine
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Kurokawa Kiyoshi
The First Department Of Internal Medicine Faculty Of Medicine University Of Tokyo
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