アルカリフオスフアターゼを分泌していた腎腫瘍の1例 : 腎由来のアルカリフオスフアターゼ・アイソザイムについての考察

概要

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A 47 year-old female was admitted to the Hospital because of unknown fever and general malaise. She was found to show extremely high serum alkaline phosphatase (Al-P) without metastasis or cardiac insufficiency, which came down to normal with improvement of clinical symptoms 2 weeks after surgery. Electrophoretic study of alkaline phosphatase from serum, urine, normal renal cortex and tumor confirmed that elevated activity of serum alkaline phosphatase was caused by the tumor itself. Alkaline phosphatase isozyme secreted from the tumor was spotted at the same area at Al-P_1 by the current gel agar method. On the other hand alkaline phosphatase isozyme from normal renal cortex appeared at the same area as Al-P_3 on electrophoresis. However, it was proved to be different from Al-P_8 by the inhibition tests by phenylalanine, urea, EDTA and heating.
社団法人日本泌尿器科学会の論文