放射性物質投与時の淋巴腺組織内脱水素酵素の組織化学的検討

概要

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Changes of the activities of succinic dehydrogenase, glucose-6-phosphate dehydrogenase and lactic dehydrogenase in lymph nodes were estimated histochemically in humans and rabbits. 1) The histochemical activities of those dehydrogenases were changed on the administration of radioisotopes before the histological changes by H. E. staining were not observed. 2) The staining intensities of those enzymes increased with lower radio activity, while they decreased with higher one. 3) In rabbits, it was noted that the activities of those enzymes decreased markedly with a large dosis of the radioisotope. Those results suggest that intralymphatic administration of radio isotopes might be useful in the treatment of malignancy and the prevention of tumor cell dissemination in lymphography. Further study would be necessary before we confirm the clinical effectiveness of this method.
社団法人日本泌尿器科学会の論文