泌尿器悪性腫瘍の化学塞栓療法に関する臨床的研究 : I, 胃癌に対する制癌剤マイクロカプセルの化学塞栓効果

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The first clinical observation on intra-arterial infusion of microencapsulated anticancer drug (MMC-m.c.) is presented. The MMC-m.c., ethylcellulose microcapsules of mitomycin C (MMC), were prepared by us to be applied for intra-arterial infusion chemotherapy and proved to provide a sustained release property in vitro as well as in vivo. Thirty cases of kidney cancer were treated by transcatheter arterial embolization. The patients were classified into 3 treated groups; A) simple mechanical embolization using Gelfoam in 4 cases, B) chemoembolization using Gelfoam and MMC of usual dosage form in 10 cases and C) chemoembolization using Gelfoam and MMC-m.c. in 16 cases. Antitumor effects on tumor reduction measured by echography, angiography or CT scan, angiographic findings and histological changes were analized in the 3 treated groups. In groups B and C, bioavailability of MMC in the systemic blood and hematological toxicity were compared.