膀胱癌のCell kineiicsに関する研究 : III. Thio-TEPA投与後にみられる細胞周期の変化とその殺細胞効果に及ぼす影響

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The cell cycle of MGH-UI cells, a cultured human bladder carcinoma cell line, were analyzed at various time points after the treatment with static dose of Thio-TEPA. Immediately after the treatment Tc (cell cycle time) prolonged by 32% of the untreated control, with a main effect in S phase. Fourtyeight hours later, that was an interval shorter than 2 cell cycle time, Tc and Ts reduced to approximately the same level as the control. However, T_<G_1> was shorter and T_<G_2> was longer as compared to the corresponding values of the control, indicating a slight accumulation of G_2 cells in the cell cycle. Reexposure at this time point to a high concentration of the agent, which was equal to cidal dose for the untreated cells, induced a regrowth of the cells. The experimental results indicate that Thio-TEPA retains a certain sensitivity on the cell cycle phases and suggest that G2 and G1 keep a crucial role for kinetics of cell killing by the agent.
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