静磁場による神経再生足場の制御(生体磁気)

概要

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Schwann cells provide a supportive role in the peripheral nervous system (PNS), forming a layer or myelin sheath along single segments of an axon. In addition, Schwann cells aid in neuronal regeneration in the PNS by guiding the regrowth of axons. In this study, we investigated the magnetic orientation of Schwann cells, and of a mixture of Schwann cells and magnetically aligned collagen, after an 8-tesla (T) magnetic field exposure produced by a superconducting magnet (bore : diameter = 100 mm, length = 700 mm, temperature = 37 ℃). We obtained and cultured Schwann cells from a dissected sciatic nerve of a neonatal rat. After three days of magnetic field exposure without collagen, Schwann cells became oriented parallel to the magnetic fields. Three-dimensional alignment of the Schwann cells along the oriented collagen fiber was observed in the mixed culture of Schwann cells and magnetically aligned collagen on the second day of culturing without magnetic fields. The magnetic control of Schwann cell alignment may be useful in medical engineering applications such as nerve regeneration.
社団法人日本磁気学会の論文
2003-04-01