拡散テンソルMRIによるひずみ推定の可能性の検討(生体磁気・医療応用)

概要

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Mechalaical stress applied on a living body influences the structure and function of the living body, and knowledge of the spatial distribution of stress in the living body is important for study of a new treatment or prevention of diseases. The mechanical stress has a close relationship to the strain. In this paper, we propose a method to estimate strain distribution in the living body based on the diffusion tensor magnetic resonance imaging technique . The computer simulation and animal experiments showed that the apparent diffusion coefficient (ADC) in the direction of cell compressing decreased when cells were compressed. The smaller the cross-sectional area of cells became, the more mean diffusivity decreased. The change of cells reflects diffusion anisotropy. From these results, we concluded that strain in a living body can be estimated using MRI.
社団法人日本磁気学会の論文
2004-03-01