拡散テンソル磁気共鳴画像法による脳内導電率のイメージング(生体磁気・医療応用)

概要

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Conductivity tensor images of a rat's brain were obtained by a method using diffusion-weighted magnetic resonance imaging (MRI). Signal attenuations in the cortex and the corpus callosum were measured using the stimulated echo acquisition mode (STEAM) sequence with a motion probing gradient (MPG). The fast and slow components of the apparent diffusion coefficient (ADC) were obtained by fitting a biexponential attenuation function to the measured signals. The conductivity tensor of the tissue was calculated from the fast component of ADC and a fraction of the fast component. The mean conductivity (MC) of the cortex and the corpus callosum were 5.1 × 10^<-2> S/m and 8.9 × 10^<-2> S/m, respectively. Using a spin-echo imaging sequence, diffusion-weighted images were obtained with b factors up to 3600 s/mm^2. Conductivity tensor images were calculated from images of the fast component of ADC and images of the fast component fraction. Tissues with highly anisotropic cellular structures, such as the corpus callosum, the internal capsule, and the trigeminal nerve, exhibited high anisotropy in conductivity.
社団法人日本磁気学会の論文
2004-04-01