経皮的磁気刺激の印加がマウス腫瘍および免疫機能に与える影響(生体磁気・医療応用)

概要

論文の詳細を見る
We investigated the effects of repetitive magnetic stimulation on tumor development processes and immune functions. A circular coil (inner diameter=15mm, outer diameter=75mm) was used in experiments. The stimulus conditions were as follows : peak magnetic field=0.25T (at the center of the coil), frequency=25 pulses/sec, 1000 pulses/sample/day. Magnetically induced eddy currents in mice=0.25T : 0.79-1.54A/m^2. B16-BL6 melanoma model mice were exposed to the magnetic stimulation for 16 days from the day after the injection of cancer cells. Tumor growth study revealed a significant decrease in the tumor weight of the stimulated group (56% vs. a sham group, 41% vs. a controls). B16-BL6 cells were also exposed to the magnetic stimulation (1000 pulses/sample). However, magnetically induced eddy currents had no effect on B16-BL6 cell viabilities. Contrary to the cell viability study, proliferation activities of mice spleen cells were up-regulated by the magnetic stimulation. TNF-α production was also activated in the stimulated mice. These results indicate that the immune functions were up-regulated by the magnetic stimulation, resulting in decreased tumor weight in the tumor model mice. And they also show the potential for therapeutic use of magnetic stimulation in cancer treatment.
社団法人日本磁気学会の論文
2005-03-01