磁場配向したフィブリン線維を取り巻く水分子のT2緩和時間(生体磁気・医療応用)

概要

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We investigated the effect of structural differences in fibrin fibers on the T_2 relaxation time. Fibrin fibers have the unique characteristic of orienting themselves parallel to high magnetic fields during polymerization. Two fibrin gels were polymerized from a fibrinogen solution with and without a 7.05-T magnetic field. Water molecules in the fibrin gel that was polymerized in the high magnetic field exhibited only one relaxation time, T_2 = 0.35 s, whereas water molecules in the fibrin gel that was not exposed to a magnetic field during polymerization had at least two exponential components in the T_2 relaxation. The long component, T_2 = 0.35 s, was the same order as the T_2 of the fibrinogen solution (= 0.41 s) and the fibrin gel polymerized in the high magnetic field. The short component was T_2 = 0.07 s. This difference is attributed to a change in the magnetic dipole-dipole interactions between water molecules and fibrin fibers.
社団法人日本磁気学会の論文
2004-03-01