Enzymatically Enantioselective Hydrolysis of Prochiral 1, 3-Diacyloxyglycerol Derivatives(Organic Chemistry)

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概要

• 論文の詳細を見る

• An enzymatically enantioselective ester hydrolysis of prochiral 1, 3-diacyloxy-2-substituted-2-propanol to chiral l-acyloxy-2, 3-propanediol was studied. The (R)-monoester was prepared by selection of a suitable lipase and alkyl chain length of the substrate diester. Lipase D from Rhizopus delemer gave (R)-l-isobutyryloxy-2-(2, 4-difluorophenyl)-2, 3-propanediol with 97%ee and 87% yield at 15℃ and pH 5.5. The (R)-monoester is a key intermediate of azole antifungal agents.

• 社団法人日本農芸化学会の論文
• 2001-09-23

著者

• Hasegawa J

  Biochemical Research Laboratories Kanegafuchi Chemical Industry Co. Ltd.

• Hasegawa J

  Life Science R & D Center Kaneka Co.

• Hasegawa Junzo

  Fine Chemicals Research Laboratories Kaneka Corporation

• YASOHARA Yoshihiko

  Fine Chemical Research Laboratories, Kaneka Corporation

• KIZAKI Noriyuki

  Fine Chemical Research Laboratories, Kaneka Corporation

• MIYAMOTO Kenji

  Lifescience Research Laboratories, Kaneka Corporation

• OHASHI Takehisa

  Lifescience Research Laboratories, Kaneka Corporation

• Kizaki Noriyuki

  Fine Chemicals Research Laboratories Kaneka Corporation

• Hasegawa J

  Ichimaru Pharcos Co. Ltd. Gifu Jpn

• Hasegawa Junzo

  Life Science Rd Center Kaneka Corporation

• Yasohara Y

  Fine Chemicals Research Laboratories Kaneka Corporation

• Yasohara Yoshihiko

  Fine Chemicals Research Laboratories

• Hasegawa J

  Fine Chemicals Research Laboratories Kaneka Corporation

• Hasegawa Junzo

  Life Science R & D Center Kaneka Co.

• Ohashi Takehisa

  Lifescience Research Laboratories Kaneka Corporation

• Yasohara Y

  Frontier Biochemical And Medicinal Research Laboratories Kaneka Corporation

• Miyamoto Kenji

  Lifescience Research Laboratories Kaneka Corporation

• Kizaki Noriyuku

  Fine Chemicals Research Laboratories, Kaneka Corporation

関連論文

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