Microbial Resolution of 2-Hydroxy-3-nitropropionic Acid for Synthesis of Optically Active Isoserine
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概要
- 論文の詳細を見る
The biocatalytic stereoselective hydrolysis of 2-hydroxy-3-nitropropionic acid esters was studied. Forty enzymes and three hundred microorganism strains were examined for their ability to hydrolyze ethyl 2-hydroxy-3-nitropropionic acid. Nocardia globerula IFO13150 gave n-butyl (R)-2-hydroxy-3-nitropropionate with a 92% enantiomeric excess (ee) and the corresponding carboxylic acid with a 92%ee, which was easily converted to (S)-isoserine, a useful β-amino acid.
- 社団法人日本農芸化学会の論文
- 2001-05-23
著者
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Hasegawa Junzo
Fine Chemicals Research Laboratories Kaneka Corporation
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YASOHARA Yoshihiko
Fine Chemical Research Laboratories, Kaneka Corporation
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Yasohara Yoshihiko
Fine Chemicals Research Laboratories Kaneka Corporation
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Yasuhara Yoshihiko
Fine Chemicals Research Laboratories, Kaneka Corporation
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