Insecticidal and Neural Activities of Candidate Photoaffinity Probes for Neonicotinoid Binding Sites(Organic Chemistry)
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概要
- 論文の詳細を見る
Photoreactive derivatives of imidacloprid and its nitromethylene analogue were synthesized as candidate photoaffinity probes for identifying the amino acid residues of nicotinic acetylcholine receptors (nAChRs) that interact with the neonicotinoid insecticides. When the candidate probes were injected into American cockroaches, the nerve cord neural activity initially increased, then ceased and death of the insect followed. Both the nerve cord and toxicity were enhanced by changing the photoreactive substituent from the para position to the meta position on the spacer benzyl moiety. When tested on a Drosophila SAD/chicken β2 hybrid, recombinant nAChR expressed in Xenopus oocytes, the nitromethylene candidate probes showed agonist activity similar to that previously observed for imidacloprid.
- 社団法人日本農芸化学会の論文
- 2001-07-23
著者
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伊原 誠
Riken Spring-8 Center
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伊原 誠
近畿大学農学部
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Ihara Makoto
RIKEN SPring-8 Center
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Matsuda Kazuhiko
Department of Applied Biological Chemistry, Graduate School of Agriculture, Kinki University
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松田 一彦
Department Of Applied Biological Chemistry School Of Agriculture Kinki University
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SATTELLE David
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford
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松田 一彦
近畿大学農学部農芸化学科
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KOMAI Koichiro
Department of Biophysics, Kobe University Graduate School of Health Sciences
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Ihara Makoto
Department of Applied Biological Chemistry, School of Agriculture, Kinki University
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KOMAI Koichiro
Graduate School of Agriculture, Kinki University
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NISHIMURA Keiichiro
Research Institute for Advanced Science and Technology, Osaka Prefecture University
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Sattelle David
Mrc Functional Genetics Unit Department Of Physiology Anatomy And Genetics University Of Oxford
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Komai Koichiro
Department Of Agricultural Chemistry Faculty Of Agriculture Kinki University
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Komai Koichiro
Graduate School Of Agriculture Kinki University
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Nishimura K
Research Institute For Advanced Science And Technology Osaka Prefecture University
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Nishimura Keiichiro
Research Institute For Advanced Science And Technology Osaka Prefecture University
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Ihara Makoto
School Of Agriculture Kinki University:(present Office)riken Harima Institute Spring-8 Center
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Ihara Makoto
Graduate School Of Agriculture Kinki Uni.
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Ihara Makoto
Department Of Applied Biological Chemistry School Of Agriculture Kinki University
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Matsuda Kazuhiko
Department Of Agricutural Chemistry Kinki University
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