Regulation of Cigarette Smoke-Induced Cytochrome P4501A1 Gene Expression in Osteogenic Disorder Shionogi Rat Liver and in Lung by Large Ascorbic Acid Dose(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
The effects of a large ascorbic acid dose on cytochrome P4501A1 gene expression induced by cigarette smoke exposure was studied in Osteogenic Disorder Shionogi rats, which lack ascorbic acid biosynthesis. The rats were divided into four groups and were administered either a minimal amount (4 mg/day, 4S and 4C) or a large amount (40 mg/day, 40S and 40C) of ascorbic acid. The 4S group and 40S group were daily exposed to cigarette smoke for 2 hours, while the 4C group and 40C group were not. At the end of the 25-day experiment, the rats were killed. The cytochrome P4501A1 mRNA level both in the liver and lung was measured by a competitive reverse transcription- polymerase chain reaction method. When a minimal amount of ascorbic acid was administered, the cytochrome P4501A1 mRNA increased in the liver of the cigarette smoke-exposed group (4S) compared with the control group (4C). On the other hand, when a large amount of ascorbic acid was administered, this increase was not observed in the cigarette smoke-induced group (40S) in liver. On the other hand, in lung, an increased mRNA level in 4S group was not decreased by large ascorbic acid administration (40S). This is the first direct mRNA-level evidence of the effects of a large ascorbic acid dose on the gene expression stimulated by cigarette smoke.
- 社団法人日本農芸化学会の論文
- 2001-11-23
著者
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Nanba Eiji
Gene Research Center, Tottori University
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Nanba Eiji
鳥取大学医学部附属脳幹性疾患研究施設 脳神経小児科部門
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Nanba Eiji
北九州市立医療センター
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Nanba Eiji
Gene Research Center Tottori University
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難波 栄二
鳥取大学生命機能研究支援センター遺伝子探索分野
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OTSUKA Yuzuru
Graduate School of Humanities and Sciences, Ochanomizu University
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Nanba E
鳥取大学生命機能研究支援センター遺伝子探索
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SUZUKI Emiko
Faculty of Pharmaceutical Sciences, Nagoya City University
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Otsuka Y
Faculty Of Education Tottori University
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Otsuka Yuzuru
Department Of Environmental Sciences Tottori University
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Nanba E
Tottori Univ. Yonago Jpn
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Nanba Eiji
Division Of Functional Genomics Tottori University
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Nanba Eiji
The Gene Research Center Tottori University
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Suzuki E
Ajinomoto Co. Inc. Kawasaki Jpn
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KURATA Tadao
Institute of Environmental Science for Human Life, Ochanomizu University
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Otsuka Yuzuru
Faculty Of Education Tottori University
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Kurata T
Faculty Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Kurata Tadao
Institute Of Environmental Science For Human Life Ochanomizu University
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Ueta E
School Of Health Science Faculty Of Medicine
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Ueta Etsuko
School Of Health Science Faculty Of Medicine Tottori University
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Ueta Etsuko
Gene Research Center Tottori University
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UETA Etsuko
Institute of Environmental Science for Human Life, Ochanomizu University
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TADOKORO Yuko
Institute of Environmental Science for Human Life, Ochanomizu University
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Tadokoro Yuko
Institute Of Environmental Science For Human Life Ochanomizu University
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Suzuki Emiko
Faculty Of Life Science Ochanomizu University
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Kurata Tadao
Niigata Univ. Pharmacy And Applied Sci. Niitsu Jpn
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Nanbu Eiji
Division Of Functional Genomics Research Center For Bioscience And Technology Tottori University
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KURATA Tadao
Institute of Environmental Science for Human Life
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