Synthetic Studies on Polysaccharide HS-142-1, a Novel Nonpeptide Antagonist for the Atrial Natriuretic Peptide Receptor: Syntheses of the Gentiobiosyl Fragments
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概要
- 論文の詳細を見る
Possible disaccharide fragments of the major component of HS-142-1, a novel polysaccharide antagonist for functional atrial natriuretic peptide (ANP) receptors, O-(4-O-caproyl-β-D-glucopyranosyl)-(1→6)-4-O-caproyl-D-glucopyranose (1) and O-(3-O-caproyl-β-D-glucopyranosyl)-(1→6)-3-O-caproyl-D-glucopyranose (2), were respectively synthesized in a stereo- and regio-controlled manner. Deprotection of 2,2'-di-O-caproyl derivative 35 gave a complex mixture due to undesired acyl migration. In contrast, 2,4'-di-O-caproyl analog 39 was successfully deprotected to give O-(4-O-caproyl-β-D-glucopyranosyl)-(1→6)-2-O-caproyl-D-glucopyranose (40).
- 社団法人日本農芸化学会の論文
- 1996-06-23
著者
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Ogawa T
Shinshu Univ. Nagano Jpn
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Ogawa T
Univ. Tokushima Tokushima Jpn
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Ogawa Tomoya
Department Of Physics Gakushuin University
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Nakahara Yoshiaki
The Institute of Physical and Chemical Research (RIKEN)
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Qiu Yi
The Institute Of Physical And Chemical Research (riken)
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OGAWA Tomoya
Graduate School for Agriculture and Life Sciences, The University of Tokyo
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Ogawa T
Space Simulation Group National Institute Of Information And Communications Technology
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Ogawa Tomoya
Space Simulation Group, National Institute of Information and Communications Technology
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