Sulfatide, a Specific Sugar Ligand for L-Selectin, Blocks CCl_4-induced Liver Inflammation in Rats

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概要

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• The effects of sulfatide, which is a specific sugar ligand for L-selectin (LECAM-1), on CCl_4-induced liver inflammation was studied in rats. Intramuscular pretreatment with sulfatide suppressed the levels of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) that were increased by CCl_4 injection, but galactosylceramide, a desulfated form of sulfatide, did not. A light-microscopic analysis found that the extent and the severity of lesions of the liver cells induced by CCl_4 injection were significantly less in the rats treated with sulfatide. These results show that sulfatide suppresses the CCl_4-induced liver inflammation by inhibiting the attachment of L-selectin expressing lymphocytes to their native sugar legends.

• 社団法人日本農芸化学会の論文
• 1995-01-23

著者

• SUZUKI Yasuo

  Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences, Core Research

• Kato Kazuo

  Biochemistry Research Laboratories, JCR Pharmaceuticals Co., Ltd.

• Kajihara Jun-ichi

  Biochemistry Research Laboratories Jcr Pharmaceuticals Co. Ltd.

• Guoji Ye

  Biochemistry Research Laboratories, JCR Pharmaceuticals Co., Ltd.

• Guoji Ye

  Biochemistry Research Laboratories Jcr Pharmaceuticals Co. Ltd.

• Suzuki Yasuo

  Department Of Applied Physics Faculty Of Engineering Fukui University

• Kato Kazuo

  Biochemistry Research Laboratories Jcr Pharmaceuticals Co. Ltd.

• Suzuki Yasuo

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Science

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