PPD によるツ反応における即時型皮膚反応の特異性について

概要

論文の詳細を見る
In skin testing with PPD, in addition to delayed reaction, immediate reaction was observed as follows: The reaction reached the maximum within 10 to 15 min and was characterized by a definite wheal and marked erythema, accompanied sometimes by pseudopodia. In immediate reaction to PPD, results were as follows: (1) The immediate reaction to PPD was observed in about 43% of children with pulmonary tuberculosis and in about 16% of healthy children previously vaccinated with BCG. (2) Whenever the immediate reaction to PPD was positive, the delayed reaction was also positive. (3) the immediate reaction was produced at a lower concentration of PPD in children with pulmonary tuberculosis than in healthy children. (4) The immediate reaction fell positive sometimes at a lower concentration of PPD than that of the delayed reaction. (5) There was an optimal concentration of PPD capable of eliciting the immediate reaction in individuals with a range of optimal concentrations varying widely according to subject. (6) Passive transfer tests to recipients via serum of donors who reacted strongly positive for the immediate reaction was successfully accomplished. From these results, it might be concluded that the immediate reaction to PPD was of a specific nature due to an antigen-antibody reaction based upon previous sensitization.
日本アレルギー学会の論文
1969-12-30