食餌アレルギーの立場からみた起立性蛋白尿

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The mechanism of orthostatic albuminuria is not clear. On close observation, many cases are found to be accompanied by symptoms due to food allergy such as fatigability, dizziness, nausea, weakness, palpitation, headache, abdominal pain, mothion sickness and so on. In this study 16 cases of orthostatic albuminuria were studied from the standpoint of food allergy, and in all cases food allergens were confirmed clinically. Urinary albumin was checked and measured semirquantitatively with Albustix. In our study, the diagnosis of orthostatic albuminuria was made when the early morning specimen was negative for urinary protein, when albuminuria appeared on upright posture or erect-lordosis, and when complete disappearance of albumin was recognized on lying down. As the results, food allergens were determined in all the 16 cases, including 2 cases in which orthostatic albuminuria appeared exclusively was seen, 8 cases in which association of symptoms such as dizziness, fatigability, weakness, discomfort and pallor were found, and 6 cases in which food allergy conditions such as duodenal ulcer, gastric ulcer, migrain, urticaria, eczema, chronic gastritis were accompanied. Of the 16 cases, the allergen was determined to be milk in 5, egg in 2, soybean in 1, milk and egg in 5, milk and soybean in 1, and milk, egg and soybean in 2 cases. Thus, orthostatic albuminuria was related to milk in 13, and to egg in 9 of 16 cases, and these two were thought to be the important allergens for developing orthostatic albuminuria. Next, urinary excretion of milk or egg antigens were studied by PCA technique in 5 out of 16 cases. The PCA reatcion was negative for the early morning specimen before giving milk or egg. Upon the erects lordotic posture, however, urinary excretion of antigens were demonstrated in all the cases from titer of 1:10 to 1:1,000. Simultaneously, a large amount of protein appeared in the urine. It is quite interesting that the urinary excretion of the antigens is paralel to the appearance of protein on erect lordosis. In this presentation, it was shown by elimination and trial ingestion diets, that food allergy may play some role in the etiology of orthostatic albuminuria.
日本アレルギー学会の論文
1967-05-30

食餌アレルギーの立場からみた起立性蛋白尿

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