小学校学童集団における起立性蛋白尿の食餌アレルギーの面からの検討

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Previously, it was demonstrated that food allergy played an important role in the etiology of Orthostatic Albuminuria (OA) associated with such food allergy symptoms or diseases as migrain, eczema, gastric ulcer or duodenal ulcer, chronic gastritis, dizziness, lassitude, motion sickness and abdominal pain. Now, the following experiments were undertaken in an effort to demonstrate food allergy in the pathogenesis of OA found in healthy school children. I) OA found in healthy school children: OF 46 healthy children in one class aged 11 to 12, 18 were diagnosed as having OA upon the erect-lordotic posture; quantity of protein demonstrated by Albustix in urine was 300 mg in 5 cases; 100 mg in 6 cases and 30 mg in 7 cases. In addition, symptoms such as abdominal discomfort, headache, dizziness, eczema and papular urticaria were found to a slight degree in some of these children with OA. II) Effect of elimination of suspect food on the disappearance of OA: Upon the complete withdrawal of both milk and eggs, 11 cases showed the disappearance of albuminuria, 4 cases showed traces of albuminuria and the remaining 3 cases showed still the same amount of albuminuria as before elimination. In the latter 3 case, then, soybean and its products were completely eliminated, resulting in the disappearance of albuminuria on the erect-lordotic posture. III) Provocative test by giving the suspect food: Then, a provocative test was carried out by examining whether OA was produced or not when milk, egg or soybean was testatively given. As the result, following food allergens were confirmed to be capable of eliciting OA on the provocative test; milk for 6 cases and soybean for 3 cases, but in one case, no OA was produced even though milk, egg or soybean was given. In these cases the quantity of protein in the urine before elimination was compared with that on the provocative test; 8 cases showed the same amount of protein both times, 8 cases showed far smaller amount of protein on the provocative test than before elimination, and the remaining one showed a slighty larger amount of protein in the former than in the latter. On the provocative test with food allergen in these children, papular urticaria developed in 3 cases, nausea, headache and lassitude appeared in 4 cases within several days, in addition, cold sweating, nausea, malaise and pollor occurred in 8 cases shortly after erect-lordotic posture was taken. IV) Results of allergic skin tests: As to the skin test with lactalbumin and soybean extract, all cases were scratch test negative with the both allergens, while 3 cases were intracutaneous test positive with lactalbumin and 6 cases were positive with soybean extract. Thus, in all of 18 OA cases found in healthy school children food allergens were demmonstrated by elimination and trial ingestion diets. The result would give further support to the hypothesis that food allergy might play an important role in the etiology of OA.
日本アレルギー学会の論文
1967-09-30

小学校学童集団における起立性蛋白尿の食餌アレルギーの面からの検討

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