正常脳組織に対する放射線急性効果に関する研究

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A total of five hundred and five mice were exposed to different X-ray doses in the range of 500 to 40,000 R. at 200 kVp, 20 mA, 1.15 mm Cu, HVL (0.5 mm Cu + 0.5 mm Al), as a single dose for the whole head. Mean life span (LD50-time) of these mice exposed to 2,000 R. was 11.04 days and that of those exposed to 30,000 R. was 0.87 days. The LD50 (5 days) was 19,700 R.. High incidences of gastrointestinal bleeding, intracranial bleeding, and brain edema were found after head exposure to 2,000 and 20,000 R.. None of the mice exposed to 500 and 1,000 R. died within 300 days. Fifty-six mice were exposed to 2,000 or 20,000 R. by the same method. All the mice were sacrificed at some postirradiation period, and pathological examinations were performed. The degree of the brain tissue damage was microscopically classified into four grades of scoring with respect to severity. These microscopic evaluations were made in at least, three mice at 18 locations in the cerebellum, 36 locations in the brain stem, and six locations in the hypothalamus under 400-fold magnification. Brain tissue damage appearing before the mean life span (LD50-time) at each irradiation dosage was observed in the cerebellum and the brain stem at the higher dosage, and in the hypothalamus at the lower dosage. It was suggested that the damage in the brain stem, cerebellum, and hypothalamus caused death after the high dose of 20,000 R., and that the hypothalamic damage caused death after the low dose of 2,000 R., In addition, the intracranial bleeding may have affected their life spans.
日本脳神経外科学会の論文
1981-10-15

正常脳組織に対する放射線急性効果に関する研究

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