転移性脳腫瘍に対する大線量少分割放射線治療の試み

概要

論文の詳細を見る
From November 1976 through September 1981, 28 patients with brain metastases received the conventional therapy and 9 patients received a high-dose, few fractions radiotherapy. There were two types of deaths-neurological and systemic death. In the conventional therapy group, neurological death occurred in 61% of all cases, but no neurological death was observed in the high dose radiotherapy group. Sequential computerized tomography (CT) scans were performed to estimate the therapeutic effect in 6 patients who received the conventional therapy and in 6 patients who received the high dose radiotherapy. Therapeutic effect was estimated by palliative indices which rated changes in the volume of the contrast-enhanced area and of the perifocal low density area, and changes in the degree of contrast-enhancement of the tumor on CT scan. Many patients who received the high dose rediotherapy showed a reduction in tumor size and in the degree of contrast-enhancement, necrotic tumor tissue surrounded by lipid-laden macrophages on pathology, and a few months of neurological improvement. Preliminary results of this study suggest that high-dose, few fractions radiotherapy is effective for brain metastasis treatment.
日本脳神経外科学会の論文
1982-10-15