81 水酸化ブラシノライド類の合成と活性評価

概要

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Brassinolide (BL) analogs with an extra hydroxyl (OH) group(s), 14α-OH-BL, 25-OH-BL and 14α, 25-di-OH-BL were synthesized from BL via direct hydroxylation of the C-14 and/or -25 positions with methyl(trifluoromethyl)dioxirane, and (25S)-26-OH-BL from a known lactone. The biological evaluation of these compounds together with (20R)-20-OH-BL, 28-OH-BL and (20R)-20, 28-di-OH-BL by the rice lamina inclination test suggested that hydroxylations at C-14, -20, -25 and -26 are inactivation steps in BL metabolism, if any, in plants, and that C-28 position of BL is a promising accessory site for assembling BL-based molecular probes to investigate brassinosteroidreceptors. A set of the hydroxylated BLs in hand constructs a reference compound library for identification of extra-hydroxylated BL analogs in plants.
植物化学調節学会の論文
1999-10-01