高齢者向け経口製剤の検討 : クエン酸ナトリウム添加ゼラチン乾燥ゲル錠の物理的性質に及ぼす添加剤の影響

概要

論文の詳細を見る
Influence of additives on friability, water absorption profiles and disintegration time of dried gel tablets prepared from gelatin-addedsodium citrate was investigated for preparation of dried gel tablets having high strength, fast water absorption rate and rapid disintegration as an oral preparation for elderly patients, pour kinds of Avicel^<[○!R]> (pH101, PH301, PH-F20, RC-591NF), polyethylene glycol and poyvinylpyrrolidone were used as additives. For the additives used friability decreased with an increase in the amount of additives. The apparent water absorption rate increased with the increase in the amount of PH301. Disintegration time was shortened at the mixing ratio of 15% (w/w) in PH301 and RC-951NF. These results suggested that the addition of 15% PH301 to dried gel powders is effective. In dried gel tablets to which PH301 was added at a mixing ratio of 15%, friability increased with the decrease in compression pressure but the apparent water absorption rate and disintegration time were scarcely affected by the compression pressure.
日本医療薬学会の論文
1995-10-10