ペンタゾシンの家兎直腸吸収におよぼす坐剤基剤の影響と臨床的評価

概要

論文の詳細を見る
Effect of various bases on rabbit rectal absorption and in vitro release from suppositories containing pentazocine were investigated. Analgesic effect of pentazocine suppository on cancerous pain was also examined. Rectal suppositories were made with glycerogelatin (Gly), polyethylene glycol (PEG) and oleaginous (Witep) bases. The rate of release of pentazocine from a suppository was higher in the order of PEG, Gly and Witep bases. There was no significant difference between PEG base and Witep base in absorption of pentazocine from rabbit rectum, while Gly base gave the lowest absorption. Among 15 patients which received the administration of pentazocine suppository, the agent proved extremely useful, useful and useless in 2, 11 and 2 cases, respectively. Side effect was not observed.
1982-10-20