割線入り錠剤の分割に及ぼす結合剤の濃度の影響

概要

論文の詳細を見る
The effect of concentration of binder on dividing of scored tablets was investigated in scored tablets compressed the granules of 12-16, 16-32 and 32-48 mesh used hydroxypropylcellulose (HPC) and potato starch as binder. We obtained the following result in each binder. 1) Dividing strength of scored tablets compressed by each particle size increased with concentration of binder in each compaction force. 2) In case of the scored tablets made from granules of 12-16 and 16-32 mesh, coefficient of weight variation of tablet halves decreased with increasing concentration of binder in low compaction force. But the influence of concentration of binder decreased when the compaction force increased. 3) The scored tablets made from granules of 32-48 mesh was not affected by concentration of binder in the compaction force of this experiment.
日本医療薬学会の論文
1989-02-20