片面圧縮法における割線入り錠剤の分割性に及ぼす非平面の杵位置の影響

概要

論文の詳細を見る
The significance of the position of nonflat punch on dividing prcperties of scored tablets was investigated in several tablets prepared from excipients or granules by one side compaction method. For the excipients, lactose, perfiller[○!R] and microcrystalline cellulose were used. For the granules, sieved granules in 12-16, 16-32 and 32-48 mesh incorporating either hydroxy propyl cellulose or potato starch as binder was used. Different influence of the position of nonflat punch on dividing strength of scored tablets was observed between the case of excipients and granules. Dividing strength of scored tablets made from excipients was not affected by the position of nonflat punch. But tablets made from granules had a tendency to show high dividing strength when tablets were compressed by nonflat upper punch. Then weight variation of divided tablets showed a tendency to become less when compressed by nonflat upper punch in both tablets made from excipients and granules. It was suggested that the effect of the position of nonflat punch on dividing properties of scored tablets was caused by different pressure lines during tablet compression.
日本医療薬学会の論文