<原著>Ergonovine誘発spasm患者の冠動脈造影による冠動脈収縮・弛緩の研究

概要

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The diameter (D) of the coronary arteries was measured on the biplane selective coronary arteriograms taken before and after intravenous administration of ergonovine maleate (EM) and sublingual nitroglycerin (NTG) in 21 patients with variant angina, rest angina, syndrome X and chest pain syndrome. Thirteen patients had a positive standard for EM test (spasm group), while the other 8 did not (control group). The magnitude of coronary narrowing by EM was calculated by the equation, 100× (control. D-EM. D)/control. D, and the magnitude of coronary dilatation by NTG was given by the equation, 100× (NTG. D-control. D)/control. D. A mean narrowing by intravenous EM 0.2mg was 14.2% in the control group, while that was 18.9% in the spasm group. On the other hand, a mean dilatation by NTG was 18.6% in the control group, while that was 23.4% in the spasm group. Both the narrowing by EM and the dilatation by NTG were significantly more marked in the spasm group than in the control group. However, there were not any significant differences of both the narrowing by EM and the dilatation by NTG in the patients of spasm group between the coronary branches with spastic stenosis and the ones without the stenosis. Thus, it is concluded that the coronary artery responses to EM and NTG are considerably strong in the spasm group irrespective of spasm related branches.
近畿大学の論文
1987-03-25