外来通院本態性高血圧患者に対する降圧剤治療の評価 : 1.心拍出量測定による循環動態の検討(B 臨床的研究)

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In order to evaluate the antihypertensive drug therapy in out-patients with essential hypertension, hemodynamic studies were performed in 52 patients before and after the therapy. Non-invasive cardiac output measurement was performed by means of the earpiece dye dilution method with an automatic device for calibration of dye concentration. Results were as follows : 1. Mean arterial pressure decreased by 8.4mmHg ( p<0.001) on the averate by the single drug therapy given diuretics, beta-blocker, Ca-antagonist or clonidine. There were no significant changes in cardiac output and systemic vascular resistance. 2. By the combined drug therapy given hydralazine or rauwolfia alkaloids in addition to the above-mentioned drugs, mean arterial pressure decreased by 15.2mmHg (p<0.001) 2.8 months after the therapy and systemic vascular resistance decreased by 6.0 mmHg・m^2/1・min^<-1>, but cardiac output did not change significantly. 3. The cardiac output significantly decreased after treatment in the patients whose cardiac output was higher than the normal value, while it significantly increased in the patients with low cardiac output before treatment. There was no relationship between the grade of pressure fall and the change in cardiac output by the treatment. 4. Thiazides and combined therapy of thiazides and beta-blocker led to a decreased cardiac output, while the addition of vasodilator to the above-mentioned drugs did not make significant change in cardiac output.
近畿大学の論文
1980-09-25

外来通院本態性高血圧患者に対する降圧剤治療の評価 : 1.心拍出量測定による循環動態の検討(B 臨床的研究)

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