<原著>正常犬および神経遮断犬における酸素吸入による心筋収縮力の反応様式の差異に関する実験的研究

概要

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It has been suggested that oxygen inhalation causes a reduction in myocardial contractile force by reducing coronary blood flow and possibly by reducing sympathoadrenal activity. This study was performed to clarify to what extent, if any, the latter mechanism contributes to the reduction in myocardial contractile force during oxygen inhalation. Coronary blood flow and myocardial contractile force were measured during air and oxygen breathings in 10 open-chest mongrel dogs, before denervation (intact heart) and after bilateral vagotomy, sympathectomy and adrenalectomy and intravenous administration of propranolol, phenoxybenzamine and atropin (denervated heart). Coronary blood flow was reduced by oxygen breathing from 28.4±10.6 (air breathing) to 21.7±7.3ml/min (oxygen breathing) in intact dogs and in denervated dons from 19.4±10.8 to 14.9±8.1ml/min. Myocardial contractile force was reduced from 29.2±8.5 to 27.5±8.2mm (a reduction of 5.8 ±4.3%, P<0.001) in intact dogs, while in denervated dogs myocardial contractile force did not show any significant change by oxygen breathing (from 15.6±4.4 to 15.5±4.2mm). It was suggested that oxygen breathing causes a decrease in myocardial contractile force by changing the sympathoadrenal activity.
近畿大学の論文
1978-09-25