<原著>酸素吸入による冠疾患々者の冠動脈直径の縮小

概要

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A routine diagnostic coronary angiography was performed in 14 patients with angina pectoris or old myocardial infarction to investigate whether or not oxygen inhalation causes coronary vasoconstriction. Coronary angiography was repeated in a certain single projection during air and 100% oxygen breathings and diameters of the coronary artery were compared. Arterial pO_2 was elevated from 91.3 to 457.2 mmHg during oxygen breathing on the average. The diameter of normal coronary arteries was reduced from 2.89±1.05 mm (±SD) to 2.65±1.02 mm (a reduction of 8.9±7.0%, P<0.001) on the average. The diameter of coronary arteries distal to the narrowing of more than 50% was also reduced from 2.24±0.53 mm to 2.02±0.57 mm (a reduction of 10.1±10.7%, p<0.02) on the average. The present study indicates that coronary arteries are constricted by oxygen breathing in the normal coronary arteries as well as in the diseased arteries, and suggests that coronary flow to the ischemic myocardium might be further reduced by oxygen breathing.
近畿大学の論文
1978-04-25