<原著>冠動脈定流量灌流, 固定心筋酸素消費量下における酸素の冠血管抵抗に及ぼす作用

概要

論文の詳細を見る
It has been shown that oxygen causes a fall in myocardial oxygen consumption and an increase in coronary vascular resistance and consequently a fall in coronary blood flow. The purpose of the present study is to find whether the increase of the coronary vascular resistance by oxygen is secondary to a reduction in the myocardial oxygen consumption, or a primary effect of oxygen on the coronary vasculature. In 12 mongrel dogs, the left anterior descending coronary artery was perfused at a constant flow rate with their own blood from the femoral artery (pO_2 95 mmHg ; Air). The pO_2 of the perfusing blood was elevated to 497 mmHg (O_2) by using an artificial lung. The myocardial oxygen consumption of the perfused area was maintained constant during perfusion with air and O_2 by adjusting the heart rate by atrial pacing. The coronary vascular resistance during perfusion with air was 3.00±1.25 mmHg/ml/min, while it was elevated to 3.36±1.28 mmHg/ml/min during perfusion with O_2. This increase in the coronary vascular resistance was not dependent on the heart rate and was not related to the amount of perfusion rate or myocardial oxygen extraction. These results indicate that the coronary vasoconstriction induced by oxygen is not secondary to a reduction in myocardial oxygen need but might be a primary effect of oxygen on the coronary vascular wall.
近畿大学の論文
1976-12-28