<Originals>Effects of Nasal and Oral Inhalation of Beclomethasone Dipropionate on Pituitary-Adrenal Function : with special reference to healthy subjects and patients with bronchial asthma complicated by nasal allergy
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概要
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In the comparative trials discussed in this paper, healthy volunteers and patients with bronchial asthma complicated by nasal allergy took part in the study. Beclomethasone dipropionate inhaler (BDI) and beclomethasone dipropionate nasal spray (BDN) were administered by oral and intranasal inhalation respectively, in a total dose of 800 μg daily ; endocrine function was investigated before administration and at two and four week intervals following administration. The healthy volunteers were subdivided into two groups : group (A) received 400 μg/day of BDI plus 400 μg/day of BDN (800 μg/day of BD in all); group (B) received 800 μg/day of BDN. No volunteers in either group showed significant changes in serum cortisol and urinary 17-OHCS levels ; they also showed normal insulin loading tests before administration and at two and four week intervals after administration. No suppression of adrenocortical function was observed. The patient group was not subdivided. All patients received both BDI and BDN as described above with a total daily dose of 800 μg. In the patient group, plasma ACTH levels before administration tended to be lower than in the volunteer groups. However, concurrent use of BDI and BDN caused no tendency toward decreases in plasma ACTH and serum cortisol levels. In the volunteer groups, blood immuno-reactive beclomethasone levels increased significantly in Group A and tended to increase in Group B after administration compared with preadministration levels. In subjects who were instructed to "gargle" immediately after inhalation of the drug, no definite increase was observed. This was possibly because mouth wash by means of "gargling" prevented the absorption of beclomethasone from the oral and pharyngeal mucosa. As "gargling" had no negative effect on the course of the treatment of bronchial asthma, it is recommended that it be conducted as part of the therapeutic regimen to prevent oral or pharyngeal candidiasis.
- 近畿大学の論文
- 1980-06-28
著者
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SUNAGA Susumu
Fourth Department of Internal Medicine, Kinki University School of Medicine
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Nakajima Shigenori
The Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Takagi Ohmi
Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Sunaga Susumu
Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Ohishi Mitsuo
Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Ohishi Mitsuo
The Fourth Department Of Medicine Kinki University School Of Medicine
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TSUYA Yasuo
Fourth Department of Internal Medicine, Kinki University School of Medicine
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FUJIHARA Yoshimasa
The Fourth Department of Internal Medicine, Kinki University School of Medicine
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TSUYA Yasuo
The Fourth Department of Internal Medicine, Kinki University School of Medicine
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TAKAGI Ohmi
The Fourth Department of Internal Medicine, Kinki University School of Medicine
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UENO Hiroshi
The Fourth Department of Internal Medicine, Kinki University School of Medicine
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SUNAGA Susumu
The Fourth Department of Internal Medicine, Kinki University School of Medicine
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Tsuya Yasuo
Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Fujihara Yoshimasa
The Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Ueno Hiroshi
The Fourth Department Of Internal Medicine Kinki University School Of Medicine
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Takagi Ohmi
The Fourth Department Of Internal Medicine Kinki University School Of Medicine
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