<Originals>Immunogenetic Studies on Broncho-Pulmonary Diseases : with Special Reference to Relationship between Phenotype Frequencies and Haplotype of HLA Antigens and Various Relating Factors in Bronchial Asthma

概要

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Phenotype frequencies and haplotype of HLA antigens in 297 cases with various bronchopulmonary diseases were studied using the method of lymphocyte microcytotoxicity test. The following results were obtained. High frequencies of HLA-A2,HLA-A9,HLA-B5,HLA-B40 were recognized in normal individuals. HLA-BW21 in the patients with chronic bronchitis was higher than those in normal individuals (p<0.05). However, there were no differences of frequencies of HLA antigens in chronic pulmonary emphysema, pulmonary tuberculosis, lung cancer, pulmonary sarcoidosis, cystic fibrosis, bronchiectasis, pneumoconiosis, pulmonary alveolar microlithiasis and normal individuals. Frequencies of HLA-BW38 in the patient with nasal allergy and frequencies of HLA-B40 in the patient with bronchial asthma were higher than those in normal individuals (p<0.05). In those various factors, high serum IgE levels and high IgE antibody titers showed to be correlated to HLA-B40. We can not prove associated haplotype in atopic families. The other hand, relationship between haplotype HLA-A10,B12 and onset of the disease were suggested in family study of the patient with hypersensitivity pneumonitis. High phenotype frequencies of HLA-B5 were recognized in acute myelocytic leukemia (p<0.05). HLA-B27 was detected in all patients of ankylosing spondylitis.
近畿大学の論文
1979-09-28