B型急性肝炎の経過予測におけるHBs抗原定量の有用性

概要

論文の詳細を見る
We evaluated the usefulness of quantitative evaluation of HBsAg in outcome prediction among 133 patients with acute hepatitis B (AH-B). Patients were classified into 4 groups according to duration of HBsAg positivity as follows: less than 3 months (Group I); less than 6 months (Group II); over 6 months (Group III); and over 12 months (Group IV). An abrupt decrease in HBsAg levels was observed and HBsAg levels at 2 weeks were significantly lower than those at the initial visit in Group I (p<0.001). On the other hand, levels of HBsAg remained high at 4 weeks and 8 weeks in Groups III and IV. Furthermore, HBsAg levels showed an increase from 2 weeks to 4 weeks in Group IV. These results suggest that quantitation of HBsAg at 4 or 8 weeks after initial visit may be useful in the prediction of clinical outcome in AH-B.
2011-06-25