In vivo Photoacoustic Spectroscopic Imaging of Hemoglobin Derivatives in Thermally Damaged Tissue
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概要
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Photoacoustic (PA) spectroscopic measurement was performed for thermally damaged skin in a rat in vivo to analyze hemoglobin derivatives in the tissue. We observed PA signals at around 500 and 633 nm, which are center wavelengths of methemoglobin (MetHb) absorption peaks, at depths corresponding the uppermost dermis (${\sim}0.16$ mm) and hair follicles (${\sim}0.62$ mm), indicating formation of MetHb in these tissue regions. By scanning a PA detector on the tissue, two-dimensional PA images (tomograms) were produced. Subtraction imaging technique was used for multispectral PA tomograms to analyze specific components of hemoglobin derivatives in the tissue, by which the contrast of oxyhemogobin (HbO2)-associated PA signal has been improved and the distribution of PA signal that seems to reflect the concentration of MetHb has been visualized.
- 2009-06-25
著者
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Obara Minoru
Department Of Electrical Engineering Faculty Of Engineering Keio University
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Ashida Hiroshi
Division Of Biomedical Information Sciences National Defense Medical College Research Institute
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Sato Shunichi
Division Of Biomedical Information Sciences National Defense Medical College Research Institute
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Aizawa Kazuya
Department Of Electrical And Electronic Engineering Toyohashi University Of Technology
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Aizawa Kazuya
Department of Electronics and Electrical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
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Saitoh Daizoh
Division of Basic Traumatology, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
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Sato Shunichi
Division of Biomedical Information Sciences, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
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Ashida Hiroshi
Division of Biomedical Information Sciences, National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
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