Changes of Serum Lipoproteins by Glycation (I):Effects of Glycation on Cholesteryl Ester Transfer and Changes of Lipoproteins

概要

論文の詳細を見る
Transfers of cholesteryl esters from high density lipoproteins (HDL) to very low density lipoproteins (VLDL) were examined using VLDL and d>1.063 fractions glycated in vitro. From these results, it was found that the transfer of HDL cholesteryl ester to VLDL was accelerated by glycation. The accelerated transfer of HDL cholesteryl ester was believed to be caused by glycation of the higher density fraction of serum proteins with a density of more than d>1.063, but not by glycation of VLDL. When sera were incubated with 200mmol/l glucose for 70hr, every lipoprotein fraction was glycated while the HDL fraction was reduced significantly. Therefore. it is suggested that the increased transfer of HDL cholesteryl ester might be related to the reduction in serum HDL levels. Since HDL2 concentrations decreased and HDL3 concentrations did not change after incubation with glucose, the ratios of HDL2/HDL3 decreased.
Japan Society of Clinical Chemistryの論文